Health Conditions
Why is 35 the age when men start fathering babies who later develop serious health conditions?
http://en.wikipedia.org/wiki/Achondroplasia
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17142012
http://aje.oxfordjournals.org/cgi/content/abstract/161/9/816
http://ageofthefatherandhealthoffuture.blogspot.com/
http://www.medicalnewstoday.com/medicalnews.php?newsid=48848
http://list.web.net/archives/mnchp-l/2004-April/000508.html
35 is the cut-off age for donor sperm at the following cryobank http://www.nwcryobank.com/donor_standards.html
http://en.wikipedia.org/wiki/Paternal_age
The question is why this happens?
I always thought that the age limit worked for both men and women. The reason for that is that with advanced age it is more likely for the process called meiosis not to be very precise. Meiosis is the mechanism by which germ cells (oocytes and sperms) are formed. These germ cells are haploid and derive from disjunction of sister chromatids at Meiosis I or meiosis II. When the separation is not normal, it is called nondisjunction. This results in the production of gametes (germ cells) which have either more or less of the usual amount of genetic material, and is a common mechanism for trisomy or monosomy. Nondisjunction can occur in the meiosis I or meiosis II phases of cellular reproduction and the incidence of it increases with the age of the “parents”. This is a cause of several medical conditions in humans including trisomias and sexual disfunctions (Turner syndrome and Klinefelter Syndrome).
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